Thesis (M.Sc.) - University of Birmingham, Dept. of Rheumatology, 1990.
|Statement||Michael William Robinson.|
disorders of both the cellular and humoral immune responses, production of autoantibodies and formation of immune complexes leading to a diverse array of clinical manifestations. It is a multisystem disease involving the immune-mediated inflammation in multiple The use of tests for immune complexes to study a patient population presents some problems in interpre- tation. A test may lack sufficient sensitivity to detect all patients with significant immune complexes, or it may be so sensitive that it detects low ranges of cir- culating immune complexes in normal :// Wager et al. analyzed sera from leprosy patients using the platelet aggregation test (PAT) which had been previously suggested to be a sensitive detector of IgG complexes in other immunological and infectious diseases (55, 56) and concluded that PAT is a sensitive detector of IgG complexes peculiar to :// The ability of fixed macrophages of the reticuloendothelial system to clear circulating immune complexes was studied in 6 patients with primary sclerosing cholangitis, 5 patients with various other forms of chronic liver disease, and 12 normal control ://
Interstitial pneumonia (IP) refers to involvement of the lung parenchyma by varying degrees of inflammation and fibrosis, in contrast to airspace disease typically seen in bacterial pneumonia. IP lies in the center of a heterogenous group of diffuse interstitial lung diseases (ILDs), either idiopathic or linked to underlying disorders. One of the major categories of disorders frequently Initial immune complex—mediated vascular injury could explain the observed facts in disseminated vasculomyelinopathy; however, only some indirect evidence supports the hypothesis: the detection of circulating complexes in some patients with these disorders, the presence of systemic features compatible with immune complex disease in occasional Abstract. This chapter describes the terminology and classification criteria associated with systemic lupus erythematosus (SLE) and the related disorders of drug induced lupus, chronic cutaneous lupus, mixed connective tissue disease (MCTD), undifferentiated connective tissue disease (UCTD), overlap syndromes, antiphospholipid antibody syndrome (APS), and neonatal :// PATIENTS AND METHODS: Sera were collected from Leishmania infected patients (n = ) and healthy Sudanese (n = 93). Nineteen Sudanese anti-CCP+ RA patients
Serological investigation of patients requiring transfusion. Investigation should be guided by sections 65 and 713 of recent BCSH guidelines on pre‐transfusion compatibility procedures (Milkins et al, ). The main aims of the investigation are to determine ABO, Rh and K status of the patient and identify alloantibodies, if :// A laboratory is evaluating an enzyme ELISA for detecting an antibody to cyclic citrullinated peptide, which is a marker for RA. The laboratory includes serum from healthy volunteers and patients with other connective tissue diseases in the evaluation. These specimens determine which factor of the assay? Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the aberrant production of a broad and heterogenous group of autoantibodies. Even though the presence of autoantibodies in SLE has been known, for more than 60 years, still nowadays a great effort is being made to understand the pathogenetic, diagnostic, and prognostic meaning of such :// Employing five radioimmunoassays for immune complexes, the sera of 45 acute and 27 postacute follow-up sera from patients with acute rheumatic fever were examined. All patients experienced actue polyarthritis. Complexes were detected in 89% of acute-phase sera by one assay, 51% by two, 29% by three, and 7% by ://